OptOTrials: Optimal Two-Stage Designs for Ordered Categorical Outcomes
Functions to design and simulate optimal two-stage randomized
controlled trials (RCTs) with ordered categorical outcomes, supporting
rank-based tests and group-sequential decision rules. Methods build on
classical and modern rank tests and two-stage/Group-Sequential designs,
e.g., Park (2025) <doi:10.1371/journal.pone.0318211>. The functions
'rule()', 'op()' and 'design_table()' provide a single entry point for
constructing designs, evaluating their operating characteristics, and
tabulating several designs at once. The earlier functions, one for each
combination of test statistic and stopping rule, are retained and still
return the same values, but they are deprecated: each warns and names its
replacement, and they will be removed in the next version. Please see the
package reference manual and the vignette for details.
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